Endocrine Abstracts

Alterations in PTH circadian rhythmicity have previously been reported in Adult Growth Hormone Deficiency (AGHD) and may contribute to the pathogenesis of AGHD-related osteoporosis. However, changes in PTH circadian rhythm have not been correlated with bone mineral density (BMD) in AGHD. Serum phosphate is a likely determinant of PTH rhythm. We examined the PTH and phosphate circadian rhythms in AGHD patients with reduced (defined as femoral neck T-score <-1.0) and normal B...

BACKGROUND: AGHD is associated with reduced BMD. GHR results in improvement in BMD, however, some patients remain osteopaenic despite all appropriate pituitary hormone replacement. PTH plays an important role in bone metabolism, with anabolic effects following intermittent administration. To date the difference in PTH activity and phosphocalcium metabolism between fully replaced AGHD patients with normal and reduced BMD has not been investigated.OBJECTIVES: To determine th...

BACKGROUD: Parathyroid hormone (PTH) is normally secreted in a circadian rhythm and modulates bone turnover through the differential stimulation of receptor activator for nuclear factor kappa-B ligand (RANKL) and suppression of osteoprotegerin (OPG), both of which are fundamental factors in regulating bone turnover. We have studied the relationship between PTH and OPG over a 24-hour period.METHODS: Hourly peripheral venous blood samples were obtained fro...